Presentation:
A white to off-white aqueous suspension for parenteral administration. Each ml contains:
Procaine Penicillin 200mg
Dihydrostreptomycin Sulphate 250mg
Hydroxybenzoate Esters (as Nipasept sodium) as antimicrobial preservative 1.5mg
Sodium Formaldehyde Sulphoxylate Dihydrate as antioxidant 1.25mg

Uses:
Pen & Strep Injection is indicated for use in cattle, horses, pigs and sheep for the treatment of infections caused by, or associated with, organisms sensitive to Penicillin and/or Streptomycin including:

Arcanobacterium pyogenes, Erysipelothrix rhusiopathiae, Klebsiella pneumonia, Listeria spp, Mannheimia haemolytica, Pasteurella multocida, Staphylococcus spp, Streptococcus spp and Salmonella spp.

Pen & Strep will therefore be effective in the treatment of infections caused by susceptible organisms including:

Erysipelas; navel/joint ill; respiratory tract infections including pneumonia and atrophic rhinitis; listeriosis; meningitis; septicaemia; toxaemia associated with mastitis; urogenital tract infections; enteritis associated with Salmonella spp., salmonellosis; and the control of secondary bacterial invaders in diseases of primary viral origin.

The combination of penicillin and dihydrostreptomycin is especially useful in the treatment of mixed infections involving both Gram-positive and Gram-negative organisms.

Dosage & Administration:
The recommended daily dose for cattle, horses, pigs and sheep is 8mg procaine penicillin and 10mg dihydrostreptomycin sulphate per kg bodyweight achieved by administering 1ml Pen & Strep per 25kg bodyweight. The dose should be given once daily by deep intramuscular injection for up to three consecutive days. The maximum dose volume administered at one site should not exceed 15ml for horses, 6ml for cattle, 3ml for sheep and 1.5ml for pigs.

Withdrawal Period:
Animals must not be slaughtered for human consumption during treatment.

Sheep, Milk: Not to be used in sheep producing milk for human consumption.

Sheep, Meat: 31 days.

Cattle, Milk: 60 hours. Milk for human consumption must not be taken during treatment.

Cattle, Meat: 23 days.

Pigs, Meat: 18 days.

Horses: Not to be used in horses intended for human consumption. Treated horses may never be slaughtered for human consumption. The horse must have been declared as not intended for human consumption under national horse passport legislation.

Contraindictions, Warnings etc:
Contraindicated in known cases of hypersensitivity to penicillins. Occasionally in sucking and fattening pigs administration of this product may cause a transient pyrexia, vomiting, shivering, listlessness and incoordination. Additionally in pregnant sows and gilts, a vulval discharge which could be associated with abortion, has been reported. Care should be taken not to exceed the recommended dosage.

Pharmaceutical Precautions:
Shake the container before use.

Do not store above 25ºC. Protect from light.

Following withdrawal of the first dose, use the product within 28 days. Discard unused material.

Keep container in outer carton.

Dispose of any unused product and empty containers in accordance with guidance from your local waste regulation authority